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July 27, 2006

Dentistry and Proteomics (Omics Series, 14)

Proteomics has quickly become one of the most exciting research frontiers in modern dentistry. The two primary areas in which dental proteomics has really shone are salivary diagnostics (also known as oral fluids diagnostics or oral fluid biomarkers) and proteomics of bone and mineral structures, especially dental enamel. Because these lines of research are still very much cutting edge, the bulk of the online resources are specific articles, and websites for the labs of researchers working in these areas. There are a number of meetings and working groups being initiated in these areas. Aside from research, salivary diagnostics has attracted a great deal of commercial and investor attention, making it challenging to search for information on these topics that is appropriate for the researcher or student. For those of the selected articles listed below which link to PubMed, please note that they require a University of Michigan login to retrieve the articles. Where possible, the link provided goes directly to the article on the publisher's website.


Hu JC. Yamakoshi Y. Yamakoshi F. Krebsbach PH. Simmer JP.
Proteomics and genetics of dental enamel.
Cells Tissues Organs. 181(3-4):219-31, 2005.
PMID: 16612087 [UM login required]

Hubbard M.
Enamel proteomics and protein interactions.
Eur J Oral Sci. 2006 May;114 Suppl 1:285-6. No abstract available.
PMID: 16674700 [UM login required]

Hubbard MJ, Kon JC.
Proteomic analysis of dental tissues.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 May 5;771(1-2):211-20.
PMID: 12016000 [UM login required]

Kim JW, Seymen F, Lin BP, Kiziltan B, Gencay K, Simmer JP, Hu JC.
ENAM mutations in autosomal-dominant amelogenesis imperfecta.
J Dent Res. 2005 Mar;84(3):278-82.
PMID: 15723871

Oppenheim, Frank.
Proteomics of Human Acquired Enamel Pellicle (EP)

Simmer JP, Bartlett JD.
Kallikrein 4 is a secreted protein.
Cancer Res. 2004 Nov 15;64(22):8481-2; author reply 8482-3.
PMID: 15548723

UM School of Dentistry: Biologic and Materials Science: Division of Prosthodontics: Simmer Lab: Research: Proteomics and Genetics of Enamel and Dentin: http://www.dent.umich.edu/depts/bms/research/simmerlab/research.html

Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG.
Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches.
J Biol Chem. 2003 Feb 14;278(7):5300-8.
PMID: 12444093


Amado FML, Vitorino RMP, Domingues PMDN, Lobo MJC, Duarte JAR.
Analysis of the human saliva proteome
Expert Review of Proteomics Aug 2005 2(4):521-539
http://www.future-drugs.com/doi/abs/10.1586/14789450.2.4.521 [$$ required for article, abstract free]

Anderson JM, Oliveira F, Kamhawi S, Mans BJ, Reynoso D, Seitz AE, Lawyer P, Garfield
M, Pham M, Valenzuela JG.
Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis.
BMC Genomics. 2006 Mar 15;7:52.
PMID: 16539713

CPRMap: Clinical Proteomics: Fluid Proteomics: Salivary Proteomics: Salivary Proteomics Research Map:

Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT.
The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications.
Adv Dent Res. 2005 Jun;18(1):3-5.
PMID: 16000263

Li Y, Zhou X, St John MA, Wong DT.
RNA profiling of cell-free saliva using microarray technology.
J Dent Res. 2004 Mar;83(3):199-203.
PMID: 14981119

NIH: NIDCR: First Meeting of Salivary Diagnostics Group:

Oral-Based Diagnostics: A New York Academy of Sciences Meeting, October 10-13, 2006.

Tabak LA
A revolution in biomedical assessment: the development of salivary diagnostics
J Dent Educ. 65(12): 1335-1339 2001

Wong DT
Salivary diagnostics powered by nanotechnologies, proteomics and genomics
JADA 137 March 2006

Wong DT.
Towards a simple, saliva-based test for the detection of oral cancer 'oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance'.
Expert Rev Mol Diagn. 2006 May;6(3):267-72.
PMID: 16706730
http://www.future-drugs.com/doi/abs/10.1586/14737159.6.3.267 [$$ required for article, abstract free]

Xie H, Rhodus NL, Griffin RJ, Carlis JV, Griffin TJ.
A Catalogue of Human Saliva Proteins Identified by Free Flow Electrophoresis-based Peptide Separation and Tandem Mass Spectrometry
Molecular & Cellular Proteomics 4:1826-1830, 2005.
http://www.mcponline.org/cgi/content/abstract/4/11/1826 [UM login required]


Barnett ML, Pihlstrom BL.
Methods for enhancing the efficiency of dental/oral health clinical trials: current status, future possibilities.
J Dent Res. 2004 Oct;83(10):744-50.
PMID: 15381712

Hing KA.
Bone repair in the twenty-first century: biology, chemistry or engineering?
Philos Transact A Math Phys Eng Sci. 2004 Dec 15;362(1825):2821-50. Review.
PMID: 15539372

Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS.
Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.
Mol Cell Biol. 2003 Jul;23(13):4428-38.
PMID: 12808086

Wright JT, Hart TC.
The genome projects: implications for dental practice and education.
J Dent Educ. 2002 May;66(5):659-71.
PMID: 12056771


Pubmed search: (proteomics OR biomarkers) (dentistry OR enamel OR pellicle OR "salivary diagnostics" OR "oral fluids")

Posted by pfa at July 27, 2006 07:30 PM


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