January 29, 2007
Head's Up: Glucosamine links Atherosclerosis, Diabetes, Arthritis
Glucosamine is a popular over the counter treatment to allieve joint pain in arthritis. Glucosamine has also been receiving increasing attention in the research literature as a potential cause of diabetes. It is also linked to atherosclerosis. Glucosamine has been proposed as an ingredient in a 'vitamin cocktail' for treating Ehlers-Dahlos patients. Might it be possible that this could be another factor connecting this cluster of systemic diseases often associated with periodontitis?
Here is a recent article from UM researchers on this topic, stating that for now it is considered safe for diabetics to use glucosamine.
Stumpf JL (firstname.lastname@example.org), Lin SW.
Effect of glucosamine on glucose control.
Ann Pharmacother. 2006 Apr;40(4):694-8. Epub 2006 Mar 28.
PMID: 16569816 [Requires UM login]
"Small, short-term studies suggest that glucosamine may be used in selected patients without affecting glucose control; however, data in patients with diabetes mellitus are limited, and close monitoring for potential changes in glucose control is recommended."
Here are just a couple examples of the literature debating this relatively new topic.
Robertson LA, Kim AJ, Werstuck GH.
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Can J Physiol Pharmacol. 2006 Jan;84(1):39-48.
PMID: 16845889 [Requires UM Login]
"We hypothesize that the accumulation of intracellular glucosamine observed in conditions of chronic hyperglycaemia may promote atherogenesis via a mechanism involving dysregulated protein folding, activation of endoplasmic reticulum (ER) stress, and increased glycogen synthase kinase (GSK)-3 activity."
Buse MG. Hexosamines, insulin resistance, and the complications of diabetes: current status.
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E1-E8. Review.
PMID: 16339923 [Free]
"There are numerous papers showing a correlation between increased flux through HBP and insulin resistance; however, the causal relationship has not been established. More recent experiments in mice overexpressing GFAT in muscle and adipose tissue or exclusively in fat cells suggest that the latter develop in vivo insulin resistance via cross talk between fat cells and muscle. Although the relationship between HBP and insulin resistance may be quite complex, it clearly deserves further study in concert with its role in the complications of diabetes."
PubMed Search: glucosamine diabetes etiology
Posted by pfa at January 29, 2007 10:20 AM
I would like to share what i found that can prevent form Atherosclerosis, Diabetes, Arthritis. Your habits, diet and genetics all play a role in putting you at risk for atherosclerosis. Cigarette smoking, high fat diet, and lack of exercise are things you must avoid. If you’re on the heavy side, aim to lose some weight because obesity is likewise an important factor.Gamma mangostin, one of the xanthones found in mangosteen, is a powerful antioxidant which helps tremendously in fighting off atherosclerosis. It prevents the oxidation of bad cholesterol (LDL) by free radicals.
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