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January 31, 2007

Local News Gone Global: Pfizer in NATURE

From today's issue of NATURE.

A changing drug supply
Research cuts by the world's largest drug company reflect a challenging
outlook for the industry.

"Pfizer's announcement last week that it will cut its research marks a watershed for the pharmaceutical industry (see page 466). Until now Pfizer, the leading drug company in terms of both sales and research spending, and an important industry bellwether, has refrained from cutting its efforts to discover new drugs. Yet its $7 billion in annual R&D expenditures has failed to generate anything near the number of discoveries needed to cover those costs."

Posted by pfa at 02:18 PM | Comments (0)

January 30, 2007

Need Pics for Powerpoint? Check out Flickr -- History, Art, Pathology, Implants, and Much More

There are a lot of sources for images that you could use in your teaching, presentations, and research. You have probably already tried Google Images, which is one of the very finest image search engines. So, if Google Images is so cool, why do I want to talk about Flickr?

In Google Images, you do a search just like for web pages, by typing in keywords that describe what you want. Google finds images that have that word near the image. Sometimes the image is right on target, sometimes it is really strange. In Google Image searches there is also the question of licensing, how to find out who owns the image, is it copyrighted, and can you get permission to use it. Answering those questions can take a lot of work.

In Flickr, you can search, just like in Google, but that isn't the best feature. What makes Flickr so powerful are three main factors.

First, currency. People tend to be loading new images every day of events right around them. This has made Flickr a popular source of images for low end or local news media.

Second, groups. People with similar interests will add their images to a shared collection. Find the collection or group that matches, and you have a much better chance of finding an image that meets your need. This also puts you in touch with people who are creating the type of images you want and find useful, and you can follow that person's new work, if you wish. Flickr will even let you search for pictures just in a group.

For example, the Dentistry Library and Sindecuse Museum are both adding images to a Flickr group for images on the history and art of dentistry. You can go to that group and search for "GV Black" or "Jonathan Taft" or Michigan or bitemark or ... well, you get the idea. If you search in "dentalhistory" for "Michigan", what you find will be more connected with dentistry in Michigan than if you searched "Michigan" in either all of Flickr or Google.

Flickr: History & Art of Dentistry: http://www.flickr.com/groups/dentalhistory/

Third, licensing. In Flickr, the authors are allowed to define the level of access and licensing they wish attached to their images. As soon as you find an image, you can check to see what is expected and what you can or cannot do with the image. Now, this has its good parts and less good parts. Some people choose to block their images from showing to anyone who does not have a Flickr account. Just remember, that if you want to see everything, you might want to consider joining Flickr -- it's free! If you have a Flickr account, you can send messages to someone to ask permission to use one of their images, even if you don't know their e-mail address, so that is another advantage.

Here are some other dental-themed Flickr groups.

Dental Photography: http://flickr.com/groups/12745983@N00/

Street Dentistry: http://flickr.com/groups/streetdentistry/

Dentistry: http://flickr.com/groups/88473280@N00/

The Dentistry Library is planning to have a class on Flickr in the Bootcamp series, so please stay tuned!

Posted by pfa at 03:02 PM | Comments (0)

January 29, 2007

Head's Up: Glucosamine links Atherosclerosis, Diabetes, Arthritis

Glucosamine is a popular over the counter treatment to allieve joint pain in arthritis. Glucosamine has also been receiving increasing attention in the research literature as a potential cause of diabetes. It is also linked to atherosclerosis. Glucosamine has been proposed as an ingredient in a 'vitamin cocktail' for treating Ehlers-Dahlos patients. Might it be possible that this could be another factor connecting this cluster of systemic diseases often associated with periodontitis?

Here is a recent article from UM researchers on this topic, stating that for now it is considered safe for diabetics to use glucosamine.

Stumpf JL (jlstumpf@umich.edu), Lin SW.
Effect of glucosamine on glucose control.
Ann Pharmacother. 2006 Apr;40(4):694-8. Epub 2006 Mar 28.
PMID: 16569816 [Requires UM login]

"Small, short-term studies suggest that glucosamine may be used in selected patients without affecting glucose control; however, data in patients with diabetes mellitus are limited, and close monitoring for potential changes in glucose control is recommended."

Here are just a couple examples of the literature debating this relatively new topic.

Robertson LA, Kim AJ, Werstuck GH.
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Can J Physiol Pharmacol. 2006 Jan;84(1):39-48.
PMID: 16845889 [Requires UM Login]

"We hypothesize that the accumulation of intracellular glucosamine observed in conditions of chronic hyperglycaemia may promote atherogenesis via a mechanism involving dysregulated protein folding, activation of endoplasmic reticulum (ER) stress, and increased glycogen synthase kinase (GSK)-3 activity."

Buse MG. Hexosamines, insulin resistance, and the complications of diabetes: current status.
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E1-E8. Review.
PMID: 16339923 [Free]

"There are numerous papers showing a correlation between increased flux through HBP and insulin resistance; however, the causal relationship has not been established. More recent experiments in mice overexpressing GFAT in muscle and adipose tissue or exclusively in fat cells suggest that the latter develop in vivo insulin resistance via cross talk between fat cells and muscle. Although the relationship between HBP and insulin resistance may be quite complex, it clearly deserves further study in concert with its role in the complications of diabetes."


PubMed Search: glucosamine diabetes etiology

Posted by pfa at 10:20 AM | Comments (1)

January 25, 2007

New Articles from UM SoD Faculty: January 07

Botero TM. Shelburne CE. Holland GR. Hanks CT. Nor JE.
TLR4 mediates LPS-induced VEGF expression in odontoblasts.
Journal of Endodontics. 32(10):951-5, 2006 Oct.

Burt BA. Kolker JL. Sandretto AM. Yuan Y. Sohn W. Ismail AI.
Dietary patterns related to caries in a low-income adult population.
Caries Research. 40(6):473-80, 2006.

Fribley A. Wang CY.
Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.
Cancer Biology & Therapy. 5(7):745-8, 2006 Jul.

Golcuk K. Mandair GS. Callender AF. Sahar N. Kohn DH. Morris MD.
Is photobleaching necessary for Raman imaging of bone tissue using a green laser?.
Biochimica et Biophysica Acta. 1758(7):868-73, 2006 Jul.

Johnson EM. Flannagan SE. Sedgley CM.
Coaggregation interactions between oral and endodontic Enterococcus faecalis and bacterial species isolated from persistent apical periodontitis.
Journal of Endodontics. 32(10):946-50, 2006 Oct.

Kheterpal S. Han R. Tremper KK. Shanks A. Tait AR. O'Reilly M. Ludwig TA.
Incidence and predictors of difficult and impossible mask ventilation.
Anesthesiology. 105(5):885-91, 2006 Nov.

Leonova EV. Pennington KE. Krebsbach PH. Kohn DH.
Substrate mineralization stimulates focal adhesion contact redistribution and cell motility of bone marrow stromal cells.
Journal of Biomedical Materials Research. Part A. 79(2):263-70, 2006 Nov.

Liu Y. Wang Y. Wu C. Liu Y. Zheng P.
Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling.
Journal of Biological Chemistry. 281(46):34768-74, 2006 Nov 17.

Nguy D. Sedgley C.
The influence of canal curvature on the mechanical efficacy of root canal irrigation in vitro using real-time imaging of bioluminescent bacteria.
Journal of Endodontics. 32(11):1077-80, 2006 Nov.

Oh WS. Roumanas E.
Dental implant-assisted prosthetic rehabilitation of a patient with a bilateral maxillectomy defect secondary to mucormycosis.
Journal of Prosthetic Dentistry. 96(2):88-95, 2006 Aug.

Scott DJ. Heitzeg MM. Koeppe RA. Stohler CS. Zubieta JK.
Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity.
Journal of Neuroscience. 26(42):10789-95, 2006 Oct 18.

Towns R. Kabeya Y. Yoshimori T. Guo C. Shangguan Y. Hong S. Kaplan M. Klionsky DJ. Wiley JW.
Sera from patients with type 2 diabetes and neuropathy induce autophagy and colocalization with mitochondria in SY5Y cells.
Autophagy. 1(3):163-70, 2005 Oct-Dec.

Wei G. Jin Q. Giannobile WV. Ma PX.
Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB. Journal of Controlled Release. 112(1):103-10, 2006 May 1.

Zhou S. Kern ER. Gullen E. Cheng YC. Drach JC. Tamiya S. Mitsuya H. Zemlicka J.
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Journal of Medicinal Chemistry. 49(20):6120-8, 2006 Oct 5.

Posted by pfa at 08:38 AM | Comments (0)

January 21, 2007

Check Out the International Museum of Surgical Sciences

If you are headed to Chicago anytime soon, you might want to check out the International Museum of Surgical Sciences. They have some really amazing exhibits. This week saw the conclusion of Catherine Jacobi's exhibit, “Her Tongue: corporal and textual examinations.� Ongoing is a lecture series on pain.

Understanding Pain: http://www.imss.org/lectureSeries.htm

"This medical humanities lecture series will examine the human experience of pain from clinical, historical, and social perspectives. Lectures will be presented by health and medical professionals, and scholars who focus on pain management."

Other recent exhibits include Milestones in Medical Imaging: 21st Century Medicine, Nursing: Care for a Changing World, and many others.

Posted by pfa at 12:53 PM | Comments (1)

January 17, 2007

New: Gum Disease Associated with Pancreatic Cancer

In today's issue of the Journal of the National Cancer Institute, there is an article extending the range of diseases now known to be associated with poor oral health.

Dominique S. Michaud, Kaumudi Joshipura, Edward Giovannucci, and Charles S. Fuchs
A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals
J. Natl. Cancer Inst. 2007 99: 171-175; doi:10.1093/jnci/djk021

Posted by pfa at 05:29 PM | Comments (0)

January 16, 2007

Recipes for Dental and Other Patients

There are many different ways in which food and cooking is important to dentists and their patients. A patient might have TMJ, problems either chewing or swallowing, sensitive teeth, be wearing braces, avoiding sugar, or have other concerns. There are even recipes for how to make your own toothpaste or mouthwash! Often recipes of interest to patients in one of these groups might be helpful for other patients as well.

The Dentistry Library has a number of cookbooks available for patients in the Consumer Health section of our Reference collection. You can find these books listed in MIRLYN by searching "Cookery" as a subject heading, or the textwords "Recipes" or "Cookbook", and then refine the search to just the Dentistry Library.

In addition to our books, here are a few websites of interest on this topic.

Cathy's EC Cafe (Esophageal Cancer): http://www.eccafe.org/cnt/index.html

Dr. William Trepp, Orthodontic Specialist: Soothing Recipes: http://www.orthodontics.org/recipe.htm

Eating to Win: http://website.lineone.net/~brittan/Food/

TMJ Friends Message Board: Life: Nutrition, Recipes, Eating Concerns: Random Soft or No Chew Recipes: http://www.tmjfriends.com/forum/archive/index.php/t-860.html

Zajaczkowa, Jadwiga. A selection of dental hygiene and mouthwash products from a variety of Medieval and Renaissance sources.


You can explore, look for more, or find books to buy in the following Google search.

Google Search: ("no chew" OR swallowing OR dysphagia OR tmj OR esophageal OR oesophageal) recipes

Posted by pfa at 03:57 PM | Comments (0)

January 15, 2007

Diversity in Dentistry, MLK Day Updates

In honor of Martin Luther King Day, you might want to be aware of these innovations in dental education and leadership in the area of diversity and multicultural awareness.


ADEA strategies to enhance diversity 2005-2006: www.adea.org/ced/Docs/Strategies_ADEA.pdf



ADDM is currently pilot testing an ethnogeriatrics curriculum in five medical schools and one dental school. AMSA is providing technical assistance and limited funding to the schools and is working with each school on program development and evaluation. Note that UMMS is one of the schools! The schools are Midwestern University; East Carolina University; University of Iowa College of Dentistry; Stanford University School of Medicine; University of Medicine and Dentistry of New Jersey; University of Michigan Medical School.

Overview: http://www.amsa.org/addm/
PDF: http://www.amsa.org/addm/ECRFP.pdf#zoom=120


ADDM is currently pilot testing a cultural competency curriculum in eight medical and three dental schools. AMSA is providing technical assistance and limited funding to the schools and is working with each school on program development and evaluation. The schools are UMDNJ; Kansas City University of Medicine and Biosciences; Des Moines University Osteopathic Medical Center; Brown Medical School; Eastern Virginia Medical School; Midwestern University; University of Illinois at Chicago; University of Nebraska College of Dentistry; University of Nevada, Las Vegas School of Dental Medicine; University of North Carolina at Chapel Hill School of Medicine; University of Texas Dental Branch at Houston.

Overview: http://www.amsa.org/addm/
PDF: http://www.amsa.org/addm/CCRFP.pdf#zoom=120
ADDM Recommended Culture and Diversity Resources: http://www.amsa.org/programs/diversityres.cfm

Posted by pfa at 02:37 PM | Comments (0)

January 13, 2007

Dentistry in the News, Recent Highlights

Just a few selections showing how dentistry is being portrayed in recent news articles.


Pacifier Use Assists In Reducing Incidence Of SIDS, Study Finds (January 11, 2007): http://www.sciencedaily.com/releases/2007/01/070111104340.htm

Soxman, Jane A. Non-nutritive sucking with a pacifier: Pros and cons.
General Dentistry, January/February 2007, pages 59-62


Dentists Sink Their Teeth Into Fighting Alcoholism - Patients Approve
Wednesday January 10, 4:10 pm ET (Yahoo News): http://biz.yahoo.com/prnews/070110/clw153.html?.v=2

Alcohol screening in dental patients: The prevalence of hazardous drinking and patients’ attitudes about screening and advice
Peter M. Miller, Michele C. Ravenel, Abigail E. Shealy, and Suzanne Thomas. J Am Dent Assoc 2006; 137: 1692-1698.


Take Precaution - Stop Fluoridation: http://www.openpr.com/news/14406/Take-Precaution-Stop-Fluoridation.html

"The precautionary principle calls for preventive actions in the face of uncertain information about risks."

What Does the Precautionary Principle Mean for Evidence-Based Dentistry?
Joel Tickner, ScDa, Melissa Coffin, BAb
Journal of Evidence-based Dental Practice, Volume 6, Issue 1, Pages 6-15 (March 2006)

Posted by pfa at 03:16 PM | Comments (0)

January 12, 2007

Heavy Metal Dentistry - Or Is It Rock and Roll?

Ever heard of the band "Dentistry the Metal Chapter, an eight-piece, hard-rock cover band that includes seven students from the UMKC School of Dentistry and, for the moment, a fledgling professional baseball player"?

Kansas City Star: Brush Up On Driller Metal: http://www.kansascity.com/mld/kansascity/entertainment/music/16428102.htm

Excerpt to appreciate:
“A dental student is one of the more stressed-out lifestyles,� Johnson said. “You’ve got tests, classes, exams. When we get together and turn up the amps, it’s the ultimate release.�

NOTE to the world -- I want a band t-shirt! Really, and will pay the list price plus USPS shipping.

Posted by pfa at 03:10 PM | Comments (1)

January 11, 2007

African-American Dentists in the Military

I just discovered this marvelous free online book documenting just a few of the challenges and achievements of early efforts to promote diversity in the US Dental Corps. Along with this, please also note recent news articles highlighting the achievements of specific African American dentists in their local communities.

Hyson, John M. African-American Dental Surgeons and the U.S. Army Dental Corps, a Struggle for Acceptance, 1901-1919

"The author began collecting any data he found on African-American dental officers as a matter of policy. The material sat dormant until 1992 when a planning grant proposal for a museum exhibition on African-American dentistry was under consideration at the University of Maryland. With a mad rush, the author dug into his files for the material collected on black dentists, thus was spawned the present manuscript."

Dr. William Morgan was a Tuskegee airman. Star Tribune January 10, 2007. http://www.startribune.com/466/story/929067.html

"The dentist, who was a pioneering black fighter pilot during World War II, moved from a Pittsburgh practice to Wanamingo, Minn., in the 1960s."

Bibb's 1st black BOE member dead at 69
By Phillip Ramati
Macon Telegraph Thu, Jan. 11, 2007

Posted by pfa at 03:34 PM | Comments (0)

The King's Crown: Auctioning Off Elvis

Once upon a time, Elvis was performing, knocked himself in the mouth with a microphone, and cracked a tooth. A crown made for this event and an impression of Elvis's mouth are currently being auctioned off on eBay.

News & Observer: Check It Out: The King's Crown: http://www.newsobserver.com/105/story/531035.html

eBay: Elvis Crown and Teeth Model

Bidding ends Sunday, for those enquiring minds that want to know.

Posted by pfa at 02:58 PM | Comments (0)

January 10, 2007

Did you know there was a war on? In dentistry, I mean?

RDH, a well known journal for dental hygienists, recently published an article called "The Feud between dentists and periodontists". Just the sort of title to attract media attention, and as you might guess, it has done so.

The article is a response to the recent AAP guidelines for appropriate referral of dental patients from general dentists to periodontists. An overview of the guidelines is included in the article, as well as discussion of opinions on the guidelines and how they may differ from common practices.

So, in case you didn't know there was a conflict, here is a link to the original article for you to peruse, and a link to the AAP guidelines.

"The American Academy of Periodontology recently released some guidelines to assist general dentists on referral protocols. Guess what? Some dentists didn’t like the guidelines. How do the AAP guidelines affect you?"
RDH, January 2007, The Feud between dentists and periodontists: http://rdh.pennnet.com/display_article/281618/56/ARTCL/none/none/The-Feud-between-dentists-and-periodontists/

American Academy of Periodontology: Guidelines for the Management of Patients with Periodontal Diseases (2006) J Periodontol 2006;727:1607-1611.
Links: http://www.perio.org/resources-products/posppr3-1.html#2
PDF: http://www.perio.org/resources-products/pdf/management.pdf

Posted by pfa at 02:25 PM | Comments (0)

January 09, 2007

Upcoming Open Classes: Mirlyn, Pubmed, Electronic Journals and More

The Dentistry Library is pleased to host guest instructors Pat Martin and Anna Schnitzer for some upcoming classes teaching basic library skills. The classes are open to all on campus and appropriate for anyone who wants a refresher or update on these tools -- faculty, staff, persons assisting faculty or students.

While there is no registration required, you may wish to register in order to receive a brief reminder shortly before the class session. To register, go to the Taubman Medical Library home page and use the link for "Winter 2007".

Taubman Medical Library: http://www.lib.umich.edu/taubman

Or click here.

Thursday, January 18, 12-1pm CAIDENT
Instructor: Anna Schnitzer

Are you wondering whether to use MEDLINE via PubMed or UM-MEDSEARCH for your research? Join us for this quick session to explore the features of each system, including content comparison, a review of search features, and access to ejournals.


The Library Catalog (Mirlyn) and Electronic Journals
Tuesday, January 30, 12-1pm CAIDENT
Instructor: Pat Martin

This one hour class will provide an introduction to searching Mirlyn, the library catalog, to locate books and journals owned by the University Libraries. Attendees will be taught some of the new catalog features which can help ease the search for resources. Attention will be given to finding and navigating the variety of online full text electronic journals.

Posted by pfa at 10:49 AM | Comments (0)

Help Grad Students: Rank Faculty Crotchetiness?

This article attracted my attention this morning, and I thought it might be of interest to some of you as well.

If you can't, what do would-be graduate students really need to
know about their potential professors and departments?

The article described a presentation by Timothy Burke to the American History Association, and the subsequent vigorous discussion by both faculty and grad students in the audience. Here are just a couple highlights from the article.

"Burke wasn’t entirely serious about personality rankings, but his point — and one greeted with nods by the graduate students in the audience — was that individual characteristics of professors may be far more important to a graduate student’s success than a department’s stellar reputation or a university’s lavish resources."

Information that was recommended to be gathered and provided to new students includes this:
* Faculty advisor completion and dropout rates, time to degree, and specific jobs earned by new Ph.D.s they advised.
* Relevant tenure clocks, retirements or possible moves on the part of advising faculty.
* Graduate student funding — how much money, sources of funds, how long money lasts (for duration of degree or shorter).
* Average time for Ph.D. completion in a department.
* The exact process — both official and unofficial — of how graduate students are evaluated.
* The true scholarly strengths of a department.

"But in a sign that the crotchetiness factor is very much alive in graduate programs, several graduate students approached about being quoted in this article offered variations of: “I work with Professor X. Are you crazy?�"

Posted by pfa at 08:42 AM | Comments (0)

January 08, 2007

Upcoming Classes: Omics Databases

The Health Sciences Libraries and the Shapiro Science Library are offering a series of four workshops entitled Introduction to NCBI Resources. Sessions will cover Entrez, Blast, Genes, Genomes, and Proteins databases and will be held over the noon-hour in 2802 Med Sci II.

Introduction to NCBI Resources: Overview and Entrez -- March 8, 2006
Introduction to NCBI Resources: BLAST -- March 15, 2006
Introduction to NCBI Resources: Genes and Genomes -- March 22, 2006
Introduction to NCBI Resources: Proteins -- March 29, 2006

For complete descriptions and registration, please see Winter workshops on the Taubman Library website at http://www.lib.umich.edu/taubman/

Posted by pfa at 12:29 PM | Comments (0)

dbGaP (database of Genotype and Phenotype)

NLM and the National Center for Biotechnology Information announce the introduction of the Database of Genotype and Phenotype (dbGaP), a new database designed to archive and distribute data from genome wide association (GWA) studies. GWA studies explore the association between specific genes (genotype information) and observable traits, such as blood pressure and weight, or the presence or absence of a disease or condition (phenotype information). See the press release for more information.

dbGaP (database of Genotype and Phenotype): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gap

Posted by pfa at 10:15 AM | Comments (0)