July 16, 2007

PostGenomic Science Blog Aggregator

For those who enjoyed our podcast on science blogs, here is a newly discovered resource to help make it easier to follow the science blogosphere -- PostGenomic.

PostGenomic is an aggregator -- a source that compiles or aggregates information from a variety of sources. In this case, PostGenomic collects information from a variety of science blogs, and repackages in a way to make them more useful. It has several very nice features, including (my favorite) the option to track your favorite blog postings and see who is talking about them. It collects science blogs across domains, so is broad in scope, but I have yet to visit their main page without finding something of interest. A marvelous resource!

PostGenomic: http://www.postgenomic.com/

Staying Current with Science Blogs & Wikis: Slides ; Podcast (zipped)

Posted by pfa at 01:16 PM | Comments (2)

June 21, 2007

What are the Top Dental Journals?

According to the 2006 Journal Citation Reports, here are the top ranked journals in dentistry, oral surgery & oral medicine.

BY IMPACT FACTOR:
#1: Critical Reviews in Oral Biology & Medicine
#2: Journal of Dental Research
#3: Journal of Endodontics

BY TOTAL CITES:
#1: Journal of Dental Research
#2: Journal of Periodontology
#3: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics

BY IMMEDIACY:
#1: Periodontology 2000
#2: British Dental Journal
#3: Journal of Clinical Periodontology

BY CITED HALF LIFE:
#1: Acta Odontologica Scandinavica
#2: American Journal of Orthodontics and Dentofacial Orthopedics
#3: Angle Orthodontics

BY CURRENT ARTICLES:
#1: Journal of Oral and Maxillofacial Surgery
#2: Journal of Periodontology
#3: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics

Want to find out about the rest? Here's how to check yourself.

1. Dentistry Library homepage, top section
2. Click on WebOfKnowledge
3. Click on Journal Citation Reports
4. In left column: Select JCR Science Edition + choose year
NOTE: I don't see 2007 available yet
5. In right column: View by Subject Category
6. SUBMIT
7. Scroll down the category list to Dentistry, Oral Surgery & Medicine
8. Choose sort by Impact Factor.
9. SUBMIT

Posted by pfa at 01:08 PM | Comments (0)

March 14, 2007

Today's News: Birth Defect Discoveries

Both Harvard and University of Iowa were in the news today for discoveries related to the genomics of birth defects.

Researchers at Harvard's Joslin Diabetes Center identified a compound (Glut2) that contributes to the increased incidence of babies born with birth defects among diabetic women.

The Harvard Crimson: Researchers Find Protein To Be Harmful to Babies of Diabetics, By Michal Labik: http://www.thecrimson.com/article.aspx?ref=517654

At the University of Iowa, Briget Riley was the primary author of a recent study in PNAS describing seven new genetic mutations associated with clefting.

Scientific American: New genetic causes of facial clefts identified, by Will Dunham: http://www.sciam.com/article.cfm?chanID=sa003&articleID=A99868F5BFB00A881295083099E55A2D

Posted by pfa at 03:01 PM | Comments (0)

January 29, 2007

Head's Up: Glucosamine links Atherosclerosis, Diabetes, Arthritis

Glucosamine is a popular over the counter treatment to allieve joint pain in arthritis. Glucosamine has also been receiving increasing attention in the research literature as a potential cause of diabetes. It is also linked to atherosclerosis. Glucosamine has been proposed as an ingredient in a 'vitamin cocktail' for treating Ehlers-Dahlos patients. Might it be possible that this could be another factor connecting this cluster of systemic diseases often associated with periodontitis?

Here is a recent article from UM researchers on this topic, stating that for now it is considered safe for diabetics to use glucosamine.


Stumpf JL (jlstumpf@umich.edu), Lin SW.
Effect of glucosamine on glucose control.
Ann Pharmacother. 2006 Apr;40(4):694-8. Epub 2006 Mar 28.
PMID: 16569816 [Requires UM login]

"Small, short-term studies suggest that glucosamine may be used in selected patients without affecting glucose control; however, data in patients with diabetes mellitus are limited, and close monitoring for potential changes in glucose control is recommended."

Here are just a couple examples of the literature debating this relatively new topic.

Robertson LA, Kim AJ, Werstuck GH.
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Can J Physiol Pharmacol. 2006 Jan;84(1):39-48.
PMID: 16845889 [Requires UM Login]

"We hypothesize that the accumulation of intracellular glucosamine observed in conditions of chronic hyperglycaemia may promote atherogenesis via a mechanism involving dysregulated protein folding, activation of endoplasmic reticulum (ER) stress, and increased glycogen synthase kinase (GSK)-3 activity."

Buse MG. Hexosamines, insulin resistance, and the complications of diabetes: current status.
Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E1-E8. Review.
PMID: 16339923 [Free]

"There are numerous papers showing a correlation between increased flux through HBP and insulin resistance; however, the causal relationship has not been established. More recent experiments in mice overexpressing GFAT in muscle and adipose tissue or exclusively in fat cells suggest that the latter develop in vivo insulin resistance via cross talk between fat cells and muscle. Although the relationship between HBP and insulin resistance may be quite complex, it clearly deserves further study in concert with its role in the complications of diabetes."

WANT MORE?

PubMed Search: glucosamine diabetes etiology

Posted by pfa at 10:20 AM | Comments (1)

January 08, 2007

Upcoming Classes: Omics Databases

The Health Sciences Libraries and the Shapiro Science Library are offering a series of four workshops entitled Introduction to NCBI Resources. Sessions will cover Entrez, Blast, Genes, Genomes, and Proteins databases and will be held over the noon-hour in 2802 Med Sci II.

Introduction to NCBI Resources: Overview and Entrez -- March 8, 2006
Introduction to NCBI Resources: BLAST -- March 15, 2006
Introduction to NCBI Resources: Genes and Genomes -- March 22, 2006
Introduction to NCBI Resources: Proteins -- March 29, 2006

For complete descriptions and registration, please see Winter workshops on the Taubman Library website at http://www.lib.umich.edu/taubman/

Posted by pfa at 12:29 PM | Comments (0)

dbGaP (database of Genotype and Phenotype)

NLM and the National Center for Biotechnology Information announce the introduction of the Database of Genotype and Phenotype (dbGaP), a new database designed to archive and distribute data from genome wide association (GWA) studies. GWA studies explore the association between specific genes (genotype information) and observable traits, such as blood pressure and weight, or the presence or absence of a disease or condition (phenotype information). See the press release for more information.

dbGaP (database of Genotype and Phenotype): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gap

Posted by pfa at 10:15 AM | Comments (0)

December 18, 2006

NIH Electronic Grant Submission Workshop Series

The Health Sciences Libraries are offering a symposium series to assist grant applicants with the electronic submission of NIH grants. The workshops will be at the Biomedical Science Research Building (BSRB) Auditorium, 109 Zina Pitcher Place on the Medical School Campus.

NIH Electronic Submission and Deep Blue
- January 11, 2007 from 9 – 11 am
- Merle Rosenzweig Health Sciences Libraries and Department of Human Genetics
- Jim Ottaviani, Coordinator, Deep Blue

Deep Blue and Intellectual Property (Copyright)
- January 18, 2007 from 9 – 11 am
- Paul Newman, University Library Intellectual Property Office

NIH Electronic Submission Process
- January 25, 2007 from 9 – 11 am
- Bob Beattie, Managing Senior Project Representative, Division of Research Development & Administration (DRDA)

More information, registration, directions, and updates will be posted at the following link.

NIH Electronic Grant Submission and How Deep Blue Can Help You: http://www.lib.umich.edu/taubman/grants0612/GrantWorkshopSeries.html

Posted by pfa at 11:16 AM | Comments (0)

December 06, 2006

Neanderthal's Molars, Future Genius, Scientific Fraud, & Diagnosis in Diversity: Article Highlights from Science Journals

Interesting articles selected from new issues of Nature and Science. NOTE: You must be a UM patron to have access to these. If you are a UM patron and have trouble accessing the articles linked below, try using on on-campus computer, or accessing the articles from the Electronic Journals page.

(1)
Scientific American: Oral and Whole Body Health:
http://www.dentalcare.com/soap/products/promotion_sa.htm

"It's a first step on the journey as we work together to uncover the most important and factual information there is regarding the important role good oral health can play in achieving whole body wellness."

(2)
How Neanderthal molar teeth grew
Roberto Macchiarelli et al.
Abstract: http://www.nature.com/nature/journal/v444/n7120/abs/nature05314.html

"Here we show that the timing of molar crown and root completion in Neanderthals matches those known for modern humans but that a more complex enamel–dentine junction morphology and a late peak in root extension rate sets them apart."

(3)
Futures: Awakening the genius within, Revolution in the head.
Daniel Gregory
http://www.nature.com/nature/journal/v444/n7120/full/444788a.html

"Teetering on the knife-edge, the humans struggled against the Inspiron and the talent that it could give them."

(4)
The right tools can save lives
Effective diagnosis, paired with treatment, for developing-world
diseases can have far-reaching impacts, says the Global Health
Diagnostics Forum.
http://www.nature.com/nature/journal/v444/n7120/full/444681a.html

"The Forum has defined the need and impact of diagnostics for six devastating disease groups. Now we challenge scientists, technology developers, funding agencies, policy-makers, international governmental and aid organizations, investors and diagnostic companies to work together to take this forward. A coordinated approach is needed so that appropriate diagnostics can achieve the promised impact."


(5)
Donald Kennedy
Responding to Fraud
Science 1 December 2006
http://www.sciencemag.org/cgi/content/summary/314/5804/1353

"The committee was asked to make a thorough and unsparing analysis of Science's handling of both papers and to make recommendations for changes in procedure that might protect both the journal and the scientific community from further unfortunate outcomes of this kind.

The report, and a short response from Science, are available at www.sciencemag.org/cgi/content/full/314/5804/1353/DC1."

Posted by pfa at 03:22 PM | Comments (0)

November 21, 2006

SlideShare.net: Ready, Set, Present!

Dr. X. Pertise agreed to speak to a university group at a meeting that is coming up in two days, on a broad topic peripherally related to his own research, but for which he doesn't have appropriate slides. Dr. P. thought there would be plenty of time to just put together something quick, but something unexpected has gone haywire in the lab at the last minute. He doesn't have time to make presentation slides, so he logs onto SlideShare and looks to see if there is a presentation by anyone he knows on this topic, that he could repurpose for this talk, with appropriate attribution to the original author. A few quick keyword searches, and he has found one presentation that has some good images, another presentation with a good conceptual outline, and some recommended resources that he can easily enrich. He knows the authors, so he contacts them to request a copy of their slides. In the meantime, he sends the links to his assistant, and asks them to start assembling new presentation slides that incorporate these bits. Later, he will quickly reorganize the information the way he wants it for the presentation.

------------------------------------

Does this sound too good to be true? Pie-in-the-sky futuring? Well, tah-dah! The future has arrived. SlideShare.net allows people to share their slide presentations. It does not allow people to download the slides, only view them online, but that still can be very useful when assembling ideas in a time-dependent situation. SlideShare is a new service, so the content is still very much growing. Some of the best content is from organizations and government institutions that provide free information as advocates for a specific topic.

Still, you might be surprised what you can find. Examples include presentations on HIPAA and e-mail, four-handed dentistry, medical ethics, professionalism and education, bioinformatics, genomics, the semantic web, craniofacial anomalies, tissue engineering, drug development, and more.

The search interface is particularly sloppy, so you have to do a fair amount of digging once you get to the results. The more specific language is more useful in this circumstance. Like any of the Web 2.0 tools, the quality of what is findable will depend on people who are willing to share their content. If this would be a useful resource to have in the future, consider if it is worth sharing something of yours to make it more useful now.

Posted by pfa at 03:06 PM | Comments (0)

October 25, 2006

Bisphosphonates and Osteonecrosis of the Jaw

In support of yesterday's excellent and well attended presentation by Dr. Joseph Helman, we would like to offer the following selected resources on bisphosphonates and osteonecrosis of the jaw. Sections below include information for patients, for practitioners, and articles from the professional literature.

Please note that while links to articles and abstracts are provided as possible, to get access to the full article you may need to navigate to the article from a UM Library service. One way to do this would be to enter PubMed from a UM web page, log in if off campus, and then enter the PMID number. Go to the bottom of the resulting page, and click on the block-M.

For those who would like more information, custom searches in PubMed are provided.


* INFORMATION FOR PATIENTS

ADA: Oral Health Topics: Osteonecrosis of the Jaw: http://www.ada.org/public/topics/osteonecrosis.asp

AGD: Treatment drug may cause jaw bone to die: http://www.agd.org/media/2006/june/treatment.asp

NIAMS: Oral Health and Bone Disease: http://www.niams.nih.gov/bone/hi/oralhealth_bone.htm


* INFORMATION FOR PROFESSIONALS

ADA: A-Z Topics: Osteonecrosis of the Jaw: http://www.ada.org/prof/resources/topics/osteonecrosis.asp

ADA Council on Scientific Affairs. Expert Panel Recommendations: Dental Management of Patients on Oral Bisphosphonate Therapy. June 2006. [PDF, 159K]

Migliorati CA, Casiglia J, Epstein J, Jacobsen PL, Siegel MA, Woo SB. Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. Abstract.
J Am Dent Assoc. 2005 Dec;136(12):1658-68. Review. Erratum in: J Am Dent Assoc. 2006 Jan;137(1):26.
PMID: 16383047

NIDCR: Oral Care Provider's Reference Guide for Oncology Patients: http://www.nidcr.nih.gov/HealthInformation/DiseasesAndConditions/CancerTreatmentAndOralHealth/Oral%20Care%20Providers%20Reference%20Guide%20for%20Oncology%20Patients.htm


* ARTICLES

Badros A, Weikel D, Salama A, Goloubeva O, Schneider A, Rapoport A, Fenton R, Gahres N, Sausville E, Ord R, Meiller T.
Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. Abstract.
J Clin Oncol. 2006 Feb 20;24(6):945-52.
PMID: 16484704

Lacy MQ, Dispenzieri A, Gertz MA, Greipp PR, Gollbach KL, Hayman SR, Kumar S, Lust JA, Rajkumar SV, Russell SJ, Witzig TE, Zeldenrust SR, Dingli D, Bergsagel PL, Fonseca R, Reeder CB, Stewart AK, Roy V, Dalton RJ, Carr AB, Kademani D, Keller EE, Viozzi CF, Kyle RA.
Mayo clinic consensus statement for the use of bisphosphonates in multiple myeloma.
Mayo Clin Proc. 2006 Aug;81(8):1047-53. Review.
PMID: 16901028

Marx RE, Sawatari Y, Fortin M, Broumand V.
Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. Abstract.
J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75.
PMID: 16243172

Nase JB, Suzuki JB.
Osteonecrosis of the jaw and oral bisphosphonate treatment. Abstract.
J Am Dent Assoc. 2006 Aug;137(8):1115-9; quiz 1169-70.
PMID: 16873327

Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL.
Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases.Abstract.
J Oral Maxillofac Surg. 2004 May;62(5):527-34.
PMID: 15122554

Scully C, Madrid C, Bagan J.
Dental endosseous implants in patients on bisphosphonate therapy. Abstract.
Implant Dent. 2006 Sep;15(3):212-8.
PMID: 16966893


* WANT MORE?

Pubmed Search: Bisphosphonates and Osteonecrosis of the Jaw

Pubmed Search (Free Full Text Only): Bisphosphonates and Osteonecrosis of the Jaw

Posted by pfa at 01:12 PM | Comments (0)

September 27, 2006

Help Submitting Manuscripts to NIH

From NIH, NLM and the NIH Manuscript Submission System, there is a new online help system and user's guide to assist Principal Investigators and others in the online NIH submission process.

The NIHMS System User's Guide to Submitting a Manuscript: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=helpnihms.chapter.users

"This user's guide gives you step-by-step instructions on how to submit and approve manuscripts so that they may be placed in PMC for permanent archiving."

Posted by pfa at 08:15 PM | Comments (0)

July 20, 2006

Genetic and Genomic Information from NLM and the Genetics Home Reference (GHR) (Omics Series, 9)

The United States government, in general, and the National Library of Medicine, in particular, have taken leading roles in providing information, tools, resources, and training for biomedical and life sciences researchers and clinicians, including omics researchers. Very few people make use of the full range of resources they provide. Today, we will survey a few of the broad omics resources available, and then spend a little more time on a specific resource that tends to have information for both dental researchers and clinicians.

This is probably a good time to again mention the forthcoming short course on campus about NCBI resources.

National Center for Biotechnology Information: Short Course, September 7,2006 (Hosted by the Program in Bioinformatics, Department of Human Genetics & Taubman Medical Library): http://www.hg.med.umich.edu/ncbi/

In this course, you will see overviews and demonstrations of how to use many of the databases listed below. NLM and NCBI provide an astonishing number of databases. From their main databases page, you can browse a list of many of their offerings in this area.

NLM: NCBI: Entrez: All Databases: http://www.ncbi.nlm.nih.gov/gquery/gquery.fcgi?itool=toolbar

Here are a few of the specific databases, just to give you an idea of what you might find.

3D Domains: domains from Entrez Structure: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Domains

BLAST (Basic Local Alignment Search Tool finds regions of local similarity between sequences): http://www.ncbi.nlm.nih.gov/BLAST/

Cancer Chromosomes: cytogenetic databases: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=CancerChromosomes

CDD: conserved protein domain database: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=cdd

Gene: gene-centered information: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene

Genome Project: genome project information: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=genomeprj

Genome: whole genome sequences: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Genome

GENSAT: gene expression atlas of mouse central nervous system: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gensat

GEO DataSets: experimental sets of GEO data: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gds

GEO Profiles: expression and molecular abundance profiles: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=geo

HomoloGene: eukaryotic homology groups: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=homologene

Nucleotide: sequence database (GenBank): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Nucleotide

OMIA: online Mendelian Inheritance in Animals: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=omia

OMIM: online Mendelian Inheritance in Man: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM

PopSet: population study data sets: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PopSet

Probe: sequence-specific reagents: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=probe

Protein: sequence database: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Protein

PubChem BioAssay: bioactivity screens of chemical substances: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pcassay

PubChem Compound: unique small molecule chemical structures: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pccompound

PubChem Substance: deposited chemical substance records: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pcsubstance

SNP: single nucleotide polymorphism: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=snp

Structure: three-dimensional macromolecular structures: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Structure

Taxonomy: organisms in GenBank: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Taxonomy

UniGene: gene-oriented clusters of transcript sequences: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unigene

UniSTS: markers and mapping data: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=unists

Another source they provide is the Human Genome. This resource contains an entirely different list of great tools and resources. I encourage you to explore the Human Genome more on your own.

Human Genome (an integrated, one-stop, genomic information infrastructure for biomedical researchers): http://www.ncbi.nlm.nih.gov/genome/guide/

Last, for today, but not least, is the Genetics Home Reference (GHR). The GHR serves as a bridge between the technical information for researchers and the consumer or general public. It includes information on the correspondence between specific genes and diseases, diagnostic signs/symptoms, an much more. Although the information is for consumers, it can still be fairly technical. It includes a handbook and glossary, which helps, and provides information at a level that can also be useful for the clinician. In addition, they include a list of resources about genetic conditions specifically for clinicians.

NLM: Genetics Home Reference: http://ghr.nlm.nih.gov/

GHR: Genetics Resources for Clinicians and Health Professionals: http://ghr.nlm.nih.gov/ghr/resource/clinicians

Among their newest topics on conditions, you'll find Dentinogenesis Imperfecta and Amelogenesis Imperfecta. Among their new pages on specific genes, you'll find amelogenin (amelogenesis imperfecta 1, X-linked), dentin sialophosphoprotein (DSPP), enamelin, and matrix metallopeptidase 20 (MMP20 or enamelysin). They have also recently added information on a number of specific genes that are associated with the Charcot Marie Tooth Disease. Here is a sampling of pages on dental-related conditions and genes.

CONDITIONS:

Condition: Achondrogenesis: http://ghr.nlm.nih.gov/condition=achondrogenesis

Condition: Amelogenesis Imperfecta: http://ghr.nlm.nih.gov/condition=amelogenesisimperfecta

Condition: Dentinogensis imperfecta: http://ghr.nlm.nih.gov/condition=dentinogenesisimperfecta

Condition: Fibrodysplasia ossificans progressiva: http://ghr.nlm.nih.gov/condition=fibrodysplasiaossificansprogressiva

Condition: Greig cephalopolysyndactyly syndrome: http://ghr.nlm.nih.gov/condition=greigcephalopolysyndactylysyndrome

Condition: Platyspondylic lethal skeletal dysplasia, Torrance type: http://ghr.nlm.nih.gov/condition=platyspondyliclethalskeletaldysplasiatorrancetype

Condition: Sotos syndrome: http://ghr.nlm.nih.gov/condition=sotossyndrome

GENES:

Gene: DNM2: dynamin 2: http://ghr.nlm.nih.gov/gene=dnm2

Gene: MMP20: matrix metallopeptidase 20 (enamelysin): http://ghr.nlm.nih.gov/gene=mmp20

Gene: SH3TC2: SH3 domain and tetratricopeptide repeats 2: http://ghr.nlm.nih.gov/gene=sh3tc2

Gene: YARS: tyrosyl-tRNA synthetase: http://ghr.nlm.nih.gov/gene=yars

Posted by pfa at 02:16 PM | Comments (0)

July 18, 2006

Periodontitis or Biofilms as a Source of Disease?

As a break from the Omics blog series, I'd like to just mention an interesting article recently released from the CDC.

O'Connor SM, Taylor CE, Hughes JM. Emerging infectious determinants of chronic diseases. Emerg Infect Dis 2006 Jul. http://www.cdc.gov/ncidod/EID/vol12no07/06-0037.htm

To my mind, this sounded like it really ought to mention some of the recent research in dentistry linking periodontal infections and heart disease. This article doesn't do that, but it does mention biofilms as being related to this line of research. More generally, it is a very interesting overview of research in many different areas of medicine linking various infectious agents with chronic diseases, including cancer. Worth a look.

Posted by pfa at 05:55 PM | Comments (0)

July 10, 2006

Introducing our Omics Blog Series

This time of year, new graduate students are flooding into the School and faculty are intensely working on their research projects while the teaching course load is somewhat lighter than during September through May.

While there are a variety of research areas and interests, the University of Michigan and the School of Dentistry have a committed interest in the research areas that have come to be known popularly as "Omics" (genomics, proteomics, nanotechnology, and related bioinformatics concepts).

In the interests of providing useful information for those working in these areas and those who would like to know more about what their colleagues might be doing, the Dentistry Library today begins a roughly two week series of blog entries on OMICS.

The entire collection of entries will be collected at this location, with more added periodically in the future:

http://mblog.lib.umich.edu/dentlib/archives/resources/research/omics/index.html

Posted by pfa at 01:40 PM | Comments (1)

July 06, 2006

Dentistry @ Nature

dentistry@nature.com: http://www.nature.com/dentistry/index.html

If you haven't seen this section of the Nature web site, it might interest you. Nature uses these topical sections to gather journals, articles, and resources of interest all in one place. Of course, this is only the journals / articles / resources that they make available, but it is still worth checking out every once in a while. For resources, it includes job, events, and a searchable buyer's guide. Resources and positions listed focus on those of interest to the dental life-science researcher.

Posted by pfa at 04:03 PM | Comments (0)

July 03, 2006

What's Hot from the IADR (Our 100th Blog Entry)

As things wind down from the IADR meeting in Brisbane, what are the hot topics that were presented at IADR and receiving attention in the popular press? Cranberries and dentin. That's two ideas, not one.

* Cranberries

Cranberries are receiving renewed attention as a way to prevent caries. The mechanism is similar to the way cranberry juice is known to prevent and cure urinary tract infections -- preventing the bacteria from adhering to the cell surfaces. For dentistry, the idea is that cranberry juice helps to prevent S. mutans from adhering to the teeth, and thus prevents the build up of plaque.

IADR: Berry Good News for Tooth Decay Prevention, by Neil Osterweil:
http://www.medpagetoday.com/PrimaryCare/DietNutrition/tb/3647

Koo, Hyun et al. "Cranberry flavonoids on expression of virulence by S. mutans." IADR Abstract 179, presented June 28, 2006 (Brisbane).

* Dentin

Dentin is making news with the popular concept that people can grow new bone. In this case, not only new bone in general, but specifically new dentin. "The data demonstrated that AC-100 stimulated the formation of new dentin (the hard tissue of teeth that protects the tooth pulp and supports the outer enamel) when applied to tooth defects."

Acologix' AC-100 (Dentonin(R)) Phase II Data on Dentin Formation in Humans Presented at the Annual Meeting of the International Association for Dental Research: http://biz.yahoo.com/prnews/060629/sfth064.html?.v=56

Lazarov, Mirella et al. "AC-100, Novel Biological Approach to Promoting Dentin Formations in Humans." IADR Abstract 545, presented June 29, 2006 (Brisbane).

Lazarov, Mirella et al. "AC-100, A Novel Biological Agent for Dentin and Bone Regeneration." IADR Abstract 268, presented June 28, 2006 (Brisbane).

Posted by pfa at 02:59 PM | Comments (0)

June 30, 2006

New in PubMed: Related Articles Enhanced

Are you one of the many people using PubMed as your preferred source for Medline searching? Patrons who choose PubMed over OVID for MEDLINE access have told me there are two favorite features of PubMed that contribute to this choice. One is the "Single Citation Matcher" and the other is the "Related Articles" option. Well, the "Related Articles" option has just been improved.

Previously, you would do a search, and then select an article you wanted to look at, such as this one by Laurie McCauley.

McCauley LK, Tozum TF, Kozloff KM, Koh-Paige AJ, Chen C, Demashkieh M, Cronovich H, Richard V, Keller ET, Rosol TJ, Goldstein SA.
Transgenic models of metabolic bone disease: impact of estrogen receptor deficiency on skeletal metabolism.
Connect Tissue Res. 2003;44 Suppl 1:250-63.
PMID: 12952206

In the listing of articles, beside the author names, you would see the words "Related Articles, Links" as active links. If you clicked on "Related Articles", you would then receive a new list of articles that begins with the article you selected. This list is usually very long. For example, today, using the McCauley article above as the jumping-off point, there are 646 related articles.

So, what has changed? Let's say you don't want 646 related articles, at least not to start with. You have an article of interest, perhaps you might think of it as a target article. From the list, you would normally click on the authors for the target article, and this will put you in to the Abstract Display (including citation, PMID, contact information and abstract). Above the article citation, is a menu with a variety of options to customize your display. There is a new option in the "Display" menu -- "AbstractPlus". With this choice, the display gives you a blend of the "Abstract" display and the "Related Articles" -- you will see the top 5 related articles displayed beside the abstract. For the McCauley article that is our target article, these are shown like this:

--------------------
Related Links

Effects of sex steroid receptor specificity in the regulation of skeletal metabolism. [Calcif Tissue Int. 2004] PMID: 15037970
Estrogen receptor specificity in the regulation of the skeleton in female mice. [J Endocrinol. 2001] PMID: 11691642
Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss. [J Bone Miner Res. 2001] PMID: 11499861
Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice. [J Bone Miner Res. 2005] PMID: 16007339
Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice. [Eur J Endocrinol. 2005] PMID: 15745940

See all Related Articles...
--------------------

A nice feature! Try it out ...

Posted by pfa at 08:16 AM | Comments (0)

June 26, 2006

NIH on Pain and Pain Research

Findings from the NIH Pain Consortium's first symposium are now beginning to be made available to the general public. This month's consumer health newsletter from NIH (NewsInHealth) highlights the idea that a positive outlook can significantly help in pain management. Please see the links below for additional information about the Pain Consortium, the symposium (which is supposed to be made available as a webcast soon), and more.

NIH: NewsInHealth (June 2006): Ignore the Pain? Innovative Pain Management Ideas:
http://newsinhealth.nih.gov/2006/June/docs/01features_01.htm

NIH: Pain Consortium: http://painconsortium.nih.gov/

NIH Pain Consortium: First Annual Symposium, Advances in Pain Research, April 17-18, 2006: Highlights in Pain Research - Genetics, Neuronal & Glial Mechanisms, Imaging, Cognitive & Emotional Aspects, Headache, Cancer Pain, Novel Therapies, Junior Investigators:
http://conferences.masimax.com/painconsortium/agenda.cfm

NIH: Pain Consortium: NIH Pain Research: Pain Information Index: http://painconsortium.nih.gov/pain_index.html

NIH: Pain Consortium: Interactive Textbook of Pain and Symptom Research: http://painconsortium.nih.gov/symptomresearch/index.html

NIH: Pain Consortium: Pain Intensity Scales: http://painconsortium.nih.gov/pain_scales/index.html

Posted by pfa at 01:59 PM | Comments (0)

June 21, 2006

A Return to the Focal Infection Theory? Dentistry and Systemic Diseases

While preparing our forthcoming exhibit on the history of dentistry in Michigan, I stumbled across a clever little rhyme that was presented in the entertainment column of the MDA Journal.

There was a little man and he had a little fang
And a billion or so of strepto bugs were in it.
A dentist of renown said I'll put thereon a crown,
For I need all the money there is in it.
Thereupon he made a start; The bugs traveled to the heart,
Of the little man, I really hate to sing it,
For soon there was no little fang, There was no little man,
The tale's too sad, I can't go on, Oh why did I begin it?
Buzzer, A. [pseud.?] "Saydiograms." Michigan State Dental Society Bulletin (June 1924) 6:28.

With that in mind, I thought it would be interesting to highlight a few of this year's articles on the relationship between periodontal disease and various systemic diseases, a recently resurfacing concept very similar to the earlier discredited focal infection theory which, in its heyday, gave rise to the rhyme above.

Each of the articles below was published this year, and either describes a systemic disease as a complication of periodontal diseases or describes periodontal disease as a risk factor for the systemic disease. The Shetty article proposes a mechanism for this -- that the periodontal infection may contribute to immunosuppression.

Al-Zahrani MS. Kayal RA. Bissada NF. Periodontitis and cardiovascular disease: a review of shared risk factors and new findings supporting a causality hypothesis. Quintessence International. 37(1):11-8, 2006 Jan.
UI: 16429698

D'Aiuto F. Parkar M. Nibali L. Suvan J. Lessem J. Tonetti MS. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart Journal. 151(5):977-84, 2006 May.
UI: 16644317

Moss KL. Mauriello S. Ruvo AT. Offenbacher S. White RP Jr. Beck JD. Reliability of third molar probing measures and the systemic impact of third molar periodontal pathology. Journal of Oral & Maxillofacial Surgery. 64(4):652-8, 2006 Apr.
UI: 16546645

Schara R. Medvescek M. Skaleric U. Periodontal disease and diabetes metabolic control: a full-mouth disinfection approach. Journal of the International Academy of Periodontology. 8(2):61-6, 2006 Apr.
UI: 16623181

Shetty K. The role of salivary cytokines in the etiology and progression of periodontal disease. General Dentistry. 54(2):140-3; quiz 144, 2006 Mar-Apr.
UI: 16689073

Xiong X. Buekens P. Fraser WD. Beck J. Offenbacher S. Periodontal disease and adverse pregnancy outcomes: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 113(2):135-43, 2006 Feb.
UI: 16411989

Posted by pfa at 04:27 PM | Comments (0)

June 08, 2006

Clinical Researchers In the News

I've been having trouble with the mBlog software killing off my entries during editing, so please pardon me if there are several sent at once while I try to catch up.

I'd like to bring to your attention the following report of the AAMC in which they call for schools to specifically work to create the next generation of clinical researchers in their educational process.

Promoting Translational and Clinical Science: The Critical Role of Medical Schools and Teaching Hospitals (Report of the AAMC's Task Force II on Clinical Research) May 2006 [62 Pages, PDF 1 MB]: https://services.aamc.org/Publications/index.cfm?fuseaction=Product.displayForm&prd_id=150&prv_id=176

Next, did you see the International Clinical Trials Day? This was last month, so I am sorry to be late bringing this to your attention. A good idea, and I hope it receives broader attention next year. For the record, mark your calendars for May 19th.

European Clinical Research Infrastructures Network (ACRIN): International Clinical Trials' Day: http://www.ecrin.org/ecrin_files/news.php?level=1

Also of potential interest, the American Academy of Microbiology has just issued a new report on "good bugs" -- "how beneficial microbes could represent the future of medicine, with the potential to treat a variety of diseases in humans and animals from diarrhea and eczema to gum disease and autoimmune disorders."

American Academy of Microbiology (AAM) : Critical Issues Colloquia Reports: "Probiotic Microbes: The Scientific Basis," June 2006: http://www.asm.org/Academy/index.asp?bid=43351

Last but far from least for today's entry, the Public Library of Sciences has released a new journal title in collaboration with the AAMC on clinical research.

PLoS Clinical Trials: http://clinicaltrials.plosjournals.org/

Posted by pfa at 03:38 PM | Comments (0)

May 30, 2006

Online Community Tools: Streamline and Turbocharge Your Information Retrieval

A great deal of the power of science has come from collaborations. These days collaborations increasingly begin online or convert to online when one or the other participants move to another part of the country. Technology is making these connections easier in many ways. here are just a few.

The UM Research site facilitates connections among on campus researchers.

UM Research: http://www.research.umich.edu/

UM Research recommends the Community of Science, saying, "Community of Science publishes databases useful to the research community funding opportunities, in expertise, funded research, patents, and others. UM faculty and staff may search many of these databases free-of-charge." In the Community of Science, you can enter a personal profile describing your research interests, and then subscribe to a notification service for funding announcements in those areas or browse to locate other researchers working in those topics. Very useful.

UM Research: Funding: Community of Science: http://www.research.umich.edu/funding/cos.html

Community of Science: http://www.cos.com/

There are free online comunity resources also. One specifically in dentistry is the Dental Informatics Online Community, which provides "a networking platform for people interested in DI promoting the development of dental information resources, disseminate research results and encourage the formation of research and education partnerships."

Dental Informatics Online Community: http://www.dentalinformatics.com/

Not specifically dental, there are what are becoming known as folksonomy tools -- tools for 'folk' to share information, discover what other 'folk' think is worthwhile, and who the other 'folk' are interested in the same areas as you. Folksonomy tools initially were created for the general public, and over the past few years some have become available specifically for the scientific community. Here is an article about how these are being used in the scientific and research communities.

Social Bookmarking For Scientists - The Best Of Both Worlds, by Ben Lund, Nature Publishing Group, b.lund@nature.com (XTech 2006: "Building Web 2.0" — 16-19 May 2006, Amsterdam, The Netherlands):
http://xtech06.usefulinc.com/schedule/paper/75

So let's take a closer look at how this works in practice, and what you can expect to find. Here is an example of a general purpose folksonomy tool, del.icio.us. Del.icio.us is a "social bookmarking" tool. You can put your bookmarks online, keep them private or share them, and access them from any computer with a network connection. Since del.icio.us is for the general public, its greatest strengths are in finding things of interest to lots of people. Let's see what they have for dentistry or dental.

Del.icio.us: Dental: http://del.icio.us/search/?all=dental

Now, knowing that this is not the likely place to look, let's see what they have for matrix metalloproteinases or MMPs.

Del.icio.us: Metalloproteinases: http://del.icio.us/search/?all=metalloproteinases

Now, let's compare this to what we can find in Connotea for the same topic, knowing that Connotea is for scientists and clinicians, and that it collects citations for articles, not web sites.

Connotea: Metalloproteinases: http://www.connotea.org/search?q=metalloproteinases

Connotea: MMP: http://www.connotea.org/tag/mmp

There are other scientifically focused folksonomy tools, most notably CiteULike. Let's look for MMP articles in CiteULike.

CiteULike: Metalloproteinases: http://www.citeulike.org/search/all?f=title&q=metalloproteinases

Do you like anything you saw? Just checking this topic, it looks like the MMP folk are hanging out at CiteULike, so if I was doing research in that topic, that might be a resource I'd want to start considering.

If you are thinking about using any of these tools, they are especially good to keep your favorite citations handy and accessible whenever and wherever you are. Here is a helpful tool that will allow you to send your favorite references from PubMed to either Connotea or CiteULike from within the Firefox browser. Recommended only for the truly advanced technophile (a.k.a. "geek"). If there is enough interest, I'll try to do a lunch class on this for faculty.

Pubmed2Connotea / Pumed2CiteULike:
http://www.urbigene.com/pubmed2connotea/

Want to know more about Folksonomy and folksonomy tools?

Wikipedia: Folksonomy: http://en.wikipedia.org/wiki/Folksonomy

Posted by pfa at 07:38 PM | Comments (0)

May 26, 2006

Most Requested Dental Statistics

There are two particular statistics I am asked for on a fairly frequent basis -- 1) caries prevalence in various countries; and 2) distribution of dentists comparied to population for various countries. I thought perhaps it would help folks find them more easily if I post them here.

Global Statistics about Caries

WHO Oral Health Country/Area Profile Programme: http://www.whocollab.od.mah.se/index.html

International Statistics about the Dental Workforce

Global Atlas of the Health Workforce: http://www.who.int/globalatlas/DataQuery/default.asp

More International Health Statistics

FYI, WHOSIS, the statistical system from the World Health Organization, is in the process of a substantial change. For a brief time, you can still access both systems.

WHOSIS (WHO Statistical Information System): World Health Statistics 2006: http://www.who.int/whosis/en/

Posted by pfa at 04:10 PM | Comments (0)

May 25, 2006

Resources for Chemistry and Molecular Biology

Here are just a few new and different resources available free on the web for these topics.

Databases

E-Books

Posted by pfa at 03:42 PM | Comments (0)

May 17, 2006

More about Deep Blue

Remember a couple months ago when this blog posted some of the dental faculty publications included in Deep Blue? Well, now you can join those august ranks of faculty whose work will always be remembered. Why will it be remembered? Because more and more faculty are exploring options to archive publications, data, and research images for posterity with the University Library's service Deep Blue. Read on, for a recent press release on this topic.

Deep Blue -- Your work: cited more, safe forever.

The University of Michigan has more than 150 years of experience and expertise in presenting and preserving the world's best research and creativity. With Deep Blue, the UM Institutional Repository, we now have a place specifically for our faculty work. Faculty create it, deposit it online, and decide who should have access. We take care of the rest, for free.

Use it to connect with other scholars: In a cross-disciplinary study, when compared to articles that require paid access, those in systems like Deep Blue "...have consistently more citations, the advantage varying from 25%-250%."[1]

Ask your librarian or send a message to deepblue@umich.edu to get started. For more information about Deep Blue, see http://deepblue.lib.umich.edu/about/

1. Based on a study of 1,307,038 articles published from 1992-2003 in biology, psychology, sociology, health, political science, economics, education, law, business, and management. (Hajjem, Harnad, and Gingras, "Ten-Year Cross-Disciplinary Comparison of the Growth of Open Access and How It Increases Research Citation Impact." IEEE Data Engineering Bulletin, Vol. 28 No. 4, December 2005, 8pp.)

Posted by pfa at 04:06 PM | Comments (0)

April 20, 2006

New Articles from UM SoD Faculty: April 06

This is an experiment. I thought people might be interested in seeing what articles are being published by our faculty. If this is something I hear people want, I will continue to post these roughly once a month.

Posted by pfa at 08:25 AM | Comments (0)

April 18, 2006

JAMA's New Studies on Amalgam's Health Impacts

The prestigious medical journal JAMA released today two randomized controlled clinical trials on the longterm health effects of amalgam restorations in children. Both trials found no measurable ill effects of amalgam.

Neuropsychological and Renal Effects of Dental Amalgam in Children: A Randomized Clinical Trial
David C. Bellinger, PhD, MSc; Felicia Trachtenberg, PhD; Lars Barregard, MD, PhD; Mary Tavares, DMD, MPH; Elsa Cernichiari, MS; David Daniel, PhD; Sonja McKinlay, PhD.
JAMA. 2006;295:1775-1783:
FREE ARTICLE: http://jama.ama-assn.org/cgi/content/full/295/15/1775

"Conclusions In this study, there were no statistically significant differences in adverse neuropsychological or renal effects observed over the 5-year period in children whose caries were restored using dental amalgam or composite materials. Although it is possible that very small IQ effects cannot be ruled out, these findings suggest that the health effects of amalgam restorations in children need not be the basis of treatment decisions when choosing restorative dental materials."

Neurobehavioral Effects of Dental Amalgam in Children: A Randomized Clinical Trial
Timothy A. DeRouen, PhD; Michael D. Martin, DMD, PhD; Brian G. Leroux, PhD; Brenda D. Townes, PhD; James S. Woods, PhD, MPH; Jorge Leitão, MD, MS; Alexandre Castro-Caldas, MD, PhD; Henrique Luis, MS; Mario Bernardo, DMD, PhD; Gail Rosenbaum, MS; Isabel P. Martins, MD, PhD
JAMA. 2006;295:1784-1792.
UM Only: http://jama.ama-assn.org/cgi/content/short/295/15/1784

"Conclusions In this study, children who received dental restorative treatment with amalgam did not, on average, have statistically significant differences in neurobehavioral assessments or in nerve conduction velocity when compared with children who received resin composite materials without amalgam. These findings, combined with the trend of higher treatment need later among those receiving composite, suggest that amalgam should remain a viable dental restorative option for children."

Posted by pfa at 09:36 PM | Comments (0)

April 10, 2006

NLM Resource on Finding Grants

The National Library of Medicine has a new resource for persons hunting information about available grants.

NLM: FAQ: Grant Information: http://www.nlm.nih.gov/services/grant_info.html

Posted by pfa at 01:01 PM | Comments (0)

March 31, 2006

Genetic and Genomic Search Engines

The explosion of genomic and genetic information resources can make it difficult to know what are the best resources for what you need.

The single most famous and comprehensive tool is from the US government.

At Genome.gov, you can find a helpful list describing other recommended genomic and genetic tools.

Molecular Imaging Central includes a useful link section, that includes specialized search engines for genomic information. Sections of the page include "EST and STS Information", "Mapping and Inheritance Information", "Promoter Search and Corresponding Database", "Protein Motifs", and "Sequences Databases".

But new resources are always cropping up. Many are from research institutes, and may include a variety of information in addition to their own discoveries and data. Various international collaborations and journals are represented. Even corporate entities are getting involved, and there is a rumor that Google will be providing the next big genomic database. Here are just a few examples of the range of other resources available.

Posted by pfa at 03:15 PM | Comments (0)

March 20, 2006

Availability of Software Program to Assess Total Fluoride Exposure

----------- QUOTED MATERIAL ---------------

The NIDCR and NHLBI wish to announce the availability of the Nutrition Data System for Research with Fluoride (NDS-R Fluoride), the first software designed to assess total fluoride exposure of humans from both dietary and non-dietary sources. The software was developed as a new functional model for the Nutrition Data System for Research (NDS-R), a well established computerized database and interview system used by nutrition researchers for collection of dietary information and calculation of nutrient intakes.

The NDS-R Fluoride software is available on a CD-ROM accompanied by a comprehensive Online User Manual fully documenting its features and functionality and providing instructions for its use in a research setting. Training seminars also can be arranged. For information on how to license the NDS-R Fluoride software and the fee schedule contact, please see:
http://grants2.nih.gov/grants/guide/notice-files/NOT-DE-06-002.html

For additional questions or information, contact:
María Teresa Canto, DDS, MPH
Director, Health Promotion and Comunity-based Research Program
Center for Health Promotion and Behavioral Research
NIDCR/NIH/DHHS
Phone: 301-594-5497, E-mail: maria.canto@nih.gov

----------- QUOTED MATERIAL ---------------

Posted by pfa at 03:51 PM | Comments (0)

March 13, 2006

Finding Survey Instruments

If you are using or planning to use any kind of survey in research related to oral health, the Craniofacial Data Resource Center is your best one-stop shop. This includes an amazing wealth of resources for survey types of research in oral health.

NIDCR/CDC Dental, Oral, and Craniofacial Data Resource Center: Catalog of Surveys and Archive of Procedures Related to Oral Health: http://drc.nidcr.nih.gov/catalog.htm

"The Catalog of Surveys and Archive of Procedures Related to Oral Health is a two-part database linking descriptions of data sources (Catalog) with descriptions of procedures (Archive) used in the data sources. The objective of the Catalog and Archive is to provide a central and up-to-date resource for detailed descriptions of oral health data sources for public health research, program planning, and policymaking. This searchable database is available free of charge online and on CD-ROM."

Other useful free resources for health survey instruments include the following.

NCHS: NHISD: Surveys and Data Collection Systems: http://www.cdc.gov/nchs/express.htm

PROQOLID, the Patient-Reported Outcome and Quality of Life Instruments Database: http://www.proqolid.org/

Rand: Health: Surveys and Tools: http://www.rand.org/health/surveys_tools.html

Substance Abuse and Mental Health Data Archive (SAMHDA): View Survey Instruments: http://www.icpsr.umich.edu/SAMHDA/survey-inst/

In addition to these, we can also highly recommend the following databases available through the University Libraries.

More information on these types of resources is available from Taubman:

Taubman Medical Library: Guide to Test and Measurement Instruments: http://www.lib.umich.edu/taubman/eres/data/about/abouttandm.html

Posted by pfa at 02:55 PM | Comments (0)

March 09, 2006

Dental Highlights from Deep Blue

Have you heard about Deep Blue, the online institutional repository from the University of Michigan?

Deep Blue: http://deepblue.lib.umich.edu/

Deep Blue: Dentistry: http://deepblue.lib.umich.edu/simple-search?query=dentistry&start=0

Representative examples of work from faculty of the School of Dentistry include:

Posted by pfa at 03:58 PM | Comments (0)

March 07, 2006

Science in the 21st Century: Federal Resource for Talking About Research

National Science and Technology Council: Committee on Science: Science for the 21st Century: http://www.ostp.gov/nstc/21stCentury/

"The document details, from a Federal agency perspective, the science policies and accomplishments of the current Administration, and illustrates how today’s science sets the stage for benefits to the economy and national quality of life far into the future."

This thoughtful resource provides web, PDF, and presentation slides with core data and evidence to support dicussions of the value of research in our society.

Posted by pfa at 10:44 AM | Comments (0)

Zerhouni on "The NIH Investment"

Today, Dr. Zerhouni, NIH Director, is quoted as saying:

"I have made a decision that we are strategically going to educate people. We are launching a strategic ... campaign to educate the American people about the value of the NIH investment over the last 34 years," Zerhouni said. "I am sick and tired of hearing negative messages about NIH, and I am going to take on directly the job of
educating the people about the extraordinary value of the nation's investment."
Research Policy Alert (registration required): http://sacserv.com/tracking.jsp?linkid=31310&subid=3148347&campid=146997&type=0

This bold statement is echoed in earlier more formal presentations.

APA Online: Zerhouni: Cool in the Hot Seat: http://www.apa.org/ppo/issues/zerhounitest305.html
Transcript / fulltext of his presentation is in a link at the bottom of this page.
"Congress's investment in NIH has paid quantifiable human health dividends."

Fulfilling the Promise: Celebrating the Academic Medicine and NIH Collaboration: The Partnership between NIH and Academic Medicine (Zerhouni): http://www.aamc.org/research/ftp/briefings.htm
Webcast of presentation available.

NIH Fiscal Year 2006 Budget Request: http://appropriations.senate.gov/hearmarkups/Zerhouni_sStatementfinalFY2006.htm
"The American taxpayer generously invests $96 per person, per year in the NIH for the future health of our country. To give a sense of perspective about our task, I look at the total $29 billion for NIH – nearly half the discretionary funding for all of HHS—and I know I need to make sure that such a large investment is used in a strategic and systematic way to maximize the chances that better treatments and cures are rapidly developed to stem the rising burden of disease, as health care costs consume over $5,500 per person per year and are rising. NIH is currently using this investment for research to attack hundreds of common diseases and an estimated 6,000 rare diseases or conditions that affect approximately 25 million people in the United States -- diseases and disorders that may strike any of us, our parents, our children or our friends. In recent years, we have taken on new challenges such as biodefense."

Posted by pfa at 10:15 AM | Comments (0)

Genetic Association Information Network (GAIN)

Genetic Association Information Network (GAIN): www.fnih.org/GAIN/GAIN_home.shtml

"The Genetic Association Information Network (GAIN) is a public-private partnership of the Foundation for the National Institutes of Health, Inc.(FNIH), which will include corporations, private foundations, advocacy groups, concerned individuals, and the National Institutes of Health (NIH) (Overview). ... GAIN aims to release data as broadly and rapidly as possible, with equal opportunity for access by all potential research users. Unlinked genotypic data will be openly and freely accessible without need for prior approval. Linked genotypic and phenotypic data will be made available to all qualified users at the same point in time and through the same access approval mechanisms with no special access provided to GAIN partners."

Posted by pfa at 10:10 AM | Comments (0)

February 24, 2006

Upcoming Non-NIH Grant Opportunites

Please note the following upcoming grant opportunities.

Posted by pfa at 09:08 PM | Comments (0)

February 13, 2006

NIDCR: Updated Strategic Plan

NIDCR: Implementation Plan for the Updated Strategic Plan 2003-2008: http://www.nidcr.nih.gov/AboutNIDCR/StrategicPlan/ImplementationPlan.htm

In addition to research funding priorities, key areas of emphasis included clinician-patient communication and health disparities. Key words for research funding included these.

Posted by pfa at 04:09 PM | Comments (0)

January 30, 2006

Genetics and Craniofacial Disorder Resources

Today we're highlighting a few of the very fine online resources available on these topics. The Genetics Home Reference is a masterful resource made available free by the National Library of Medicine.

NLM: Genetics Home Reference: http://ghr.nlm.nih.gov/

Among their newest topics on conditions, you'll find Dentinogenesis Imperfecta and Amelogenesis Imperfecta. Among their new pages on specific genes, you'll find amelogenin (amelogenesis imperfecta 1, X-linked), dentin sialophosphoprotein (DSPP), enamelin, and matrix metallopeptidase 20 (MMP20 or enamelysin).

Highly recommended.

Another recommended resource (classic rather than current) is Jablonski's Multiple Congenital Anomaly/Mental Retardation. The information provided is core diagnositic features and a chromosome summary.

Less technical and a useful resource for patients and seeking core bibliographies on a topic is the website and database for NORD. Print copies of the book are in Reference [RC 48.8 .N3851]. The website has free content and paid content. Persons currently affiliated with the University of Michigan can get both through MIRLYN. The link below goes only to the free content.

National Organization for Rare Disorders, Inc. (NORD): http://www.rarediseases.org/

NORD usually provides links to quality patient information and public websites on the specific disorders. There are a few excellent overview sites, such as FACES: The National Craniofacial Association, Let's Face It, and World Craniofacial Foundation.

Posted by pfa at 11:47 AM | Comments (0)

January 24, 2006

Molecular Modeling and Wet Lab Tools

The Center for Molecular Modeling at NIH has a resource page listing a wide variety of molecular modeling software programs:

Universal Molecular Modeling Software List: http://cmm.info.nih.gov/modeling/software.html

They have similar resource lists for sequence analysis tools, databases, and their very useful Molecular Biology Desk Reference, that includes a variety of wet lab tools in addition to the expected reference tools. All of these resources are linked from their main resource page:

http://molbio.info.nih.gov/molbio/

Posted by pfa at 12:07 PM | Comments (0)

January 23, 2006

Bone Graft Resource

The National Library of Medicine and MedlinePlus have just announced a new information resource on bone grafts.

http://www.nlm.nih.gov/medlineplus/bonegrafts.html

The resource lists an interesting range of information, which includes the use of bone graft techniques in facial and cleft palate reconstruction.

Posted by pfa at 02:31 PM | Comments (2)